Man standing in a hallway
Man standing in a hallway

AMVUTTRA® (vutrisiran) may help you


More than 1000 adult patients in the US have chosen AMVUTTRA to treat the polyneuropathy caused by hereditary ATTR (hATTR) amyloidosis.*

Patient portrayal.*As of October 2023.

AMVUTTRA is the first and only injection given 4 times a year to treat the polyneuropathy of hATTR amyloidosis in adults

Significant improvement in nerve function and quality of life with AMVUTTRA® (vutrisiran)

Significant improvement in nerve function and quality of life

Quality of life was assessed by the Norfolk QoL-DN questionnaire that asked patients about the severity of their polyneuropathy symptoms, how often they experienced them, and what impact they felt they had on their daily lives

Nerve function was assessed using a scale called mNIS+7 that measured strength and sensation in the hands, feet, arms, and legs; reflexes; and blood pressure upon standing

AMVUTTRA® (vutrisiran) rapidly knocks down TTR

Rapidly knocked down

Walking speed was assessed using the 10-meter walk test, a stopwatch-timed measure of a patient’s walking speed over 10 meters

AMVUTTRA® (vutrisiran) is given once every 3 months by a healthcare professional

Dosing once every 3 months by a healthcare professional

Hear from patients treated with AMVUTTRA

Hear from patients treated with AMVUTTRA

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit, or call 1-800-FDA-1088.



AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.