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Feel More in the Moment

For adult patients with the polyneuropathy caused by hATTR amyloidosis, AMVUTTRA® (vutrisiran) may help you

AMVUTTRA may help your ability to participate in your daily activities

In an 18-month clinical study, AMVUTTRA-treated patients showed significant improvement in nerve function and quality of life at 9 months and continued to improve throughout the study, compared with those who received placebo in a similar study.

Significant improvement in nerve functiona and quality of lifeb

Significant improvement in walking speed, nutritional health, and ability to perform activities of daily living

Administered once every 3 months by a healthcare professionalc

aNerve function was assessed using a scale called mNIS+7 that measured strength and sensation in the hands, feet, arms, and legs; reflexes; and blood pressure upon standing. Higher scores indicate more severe disease (total score ranges from 0 to 304).

bQuality of life was evaluated by the Norfolk QoL-DN questionnaire that asked patients about the severity of their polyneuropathy symptoms, how often they experienced them, and what impact they felt they had on their daily lives. Higher scores indicate more severe impact of polyneuropathy symptoms on daily life (total score ranges from -4 to 136).

cAMVUTTRA is given once every 3 months as a subcutaneous injection by a healthcare professional, such as a doctor or nurse.

Learn more about treatment with AMVUTTRA

If you're considering treatment, this brochure may help you have a conversation about AMVUTTRA with your doctor.

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.


What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.



AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.