What to know about ATTR-CM

ATTR-CM can get worse over time

The cardiomyopathy of ATTR amyloidosis (ATTR-CM) can be caused by changes associated with aging (called wild-type ATTR) or by an inherited gene variant passed down through families (called hereditary ATTR). In both types, a protein called transthyretin (TTR) changes shape and builds up in your heart and other tissues in the body. This buildup, also known as amyloid deposits, can cause a variety of symptoms.

Symptoms of ATTR‑CM can affect the heart and other parts of the body

In people with ATTR‑CM, the heart's ability to pump blood is reduced—a condition known as cardiomyopathy, which can lead to heart failure. Below are some, but not all, of the symptoms that can occur with ATTR‑CM:

Irregular
heartbeat
Shortness
of breath
Fatigue
Leg swelling
Fainting
People may also have symptoms that are not related to the heart, which may include:
  • Digestive issues
  • Dizziness upon standing
  • Abnormal sweating
  • Sexual dysfunction
  • Weakness
  • Pain or tingling in arms or legs
  • Kidney dysfunction
  • Carpal tunnel syndrome
You may not have all of these symptoms at once or experience all of them over time. Each person with ATTR-CM has a different experience.

YOU MAY BE ABLE TO change the course of attr-cm

The symptoms of ATTR-CM can make it more difficult to walk distances, climb stairs, do things for yourself like daily chores, or enjoy outings with friends and family. If you've been diagnosed, talk to your doctor about ways to manage your condition to help slow its progression.

ATTR-CM often leads to heart failure. 
Talk to your doctor if you have new or worsening symptoms.

Learn more about ATTR‑CM

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IMPORTANT SAFETY INFORMATION

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause low vitamin A levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.  

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA were pain in the arms or legs, pain in the joints, shortness of breath, and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Indications

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the:

  • cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR‑CM) in adults to reduce heart-related death, hospital stays and urgent visits.
  • polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR‑PN) in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information.

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