Take on ATTR-CM at the source

The first and only silencer for ATTR-CM

AMVUTTRA® (vutrisiran) works with your body to reduce the production of TTR in the liver, where most of it is made.

Chart showing how AMVUTTRA limits TTR production in the liverChart showing how AMVUTTRA limits TTR production in the liver

RAPIDLY KNOCKS DOWN TTR

In a clinical study, AMVUTTRA started reducing TTR blood levels after the first dose. It rapidly knocked down TTR as early as 6 weeks and decreased TTR levels by 87% with 2.5 years of treatment.*
*Individual results may vary.
*Individual results may vary.

Build Your Personalized 
Discussion Guide

The Doctor Discussion Guide is a personalized tool that can help you have more informative conversations with your doctor about your specific needs as you manage ATTR-CM.
Start by answering the following questions. If you're the care partner of someone with ATTR-CM, complete this guide together.

Or, you can download a version to print and fill out.
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IMPORTANT SAFETY INFORMATION

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause low vitamin A levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.  

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA were pain in the arms or legs, pain in the joints, shortness of breath, and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1‑800‑FDA‑1088.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Indications

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the:

  • cardiomyopathy of wild-type or hereditary transthyretin-mediated amyloidosis (ATTR‑CM) in adults to reduce heart-related death, hospital stays and urgent visits.
  • polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR‑PN) in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information.

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