Alnylam Assist

Patient support through Alnylam Assist™

The Alnylam Assist program offers you support throughout your treatment with AMVUTTRA®. This includes helping you understand your insurance coverage for your treatment and the options for financial support for which you may be eligible. Alnylam Assist can also provide materials that may help start conversations with your doctor and family about your treatment.

Monday–Friday, 8 AM–6 PM
To learn more, visit

An Alnylam Case Manager

Once you and your doctor choose to begin treatment with AMVUTTRA, and a Start Form is submitted, a Case Manager can help you understand your insurance coverage and options for financial support based on eligibilitya, as well as provide you with educational resources. Financial assistance programs may include:

Patient Assistance Program (PAP) may be able to provide you with AMVUTTRA at no cost if you're eligible

Commercial Copay Programb covers certain out-of-pocket costs for eligible patients with commercial insurance

Alnylam Assist™ Brochure

Alnylam Assist brochure

Learn more about the patient support program available through Alnylam Assist.

aPatients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue any program at any time.

bPatients with Medicare, Medicaid, or other government-sponsored insurance are not eligible for the Alnylam Assist Commercial Copay Program. Out-of-pocket costs for the administration of AMVUTTRA will not be covered for patients residing where it is prohibited by law or where otherwise restricted.

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.


What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit, or call 1-800-FDA-1088.



AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.