Gary, treated with AMVUTTRA
Gary, treated with AMVUTTRA
Gary, treated with AMVUTTRA
How is AMVUTTRA® given?

AMVUTTRA is given once every 3 months as a subcutaneous injection by a healthcare professional, such as a doctor or nurse.

Receiving AMVUTTRA

  • AMVUTTRA is given as a subcutaneous injection in a 25 mg/0.5 mL dose
  • Subcutaneous injections are given under the skin, and the process may take a few minutes
AMVUTTRA can be given in the following areas of the body:

With AMVUTTRA, no premedications or laboratory monitoring are required.

Treatment process

Watch the video to learn more about the treatment process with AMVUTTRA
Treatment Process With AMVUTTRA video thumbnail
Treatment site options
Personal treatment journal and planner
  • AMVUTTRA may be given at your doctor’s office or other treatment sites
  • You may be eligible to have your treatment administered at home by a healthcare professional, if covered by your insurance plan. Talk to your doctor to find out if home administration is right for you

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.


What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit, or call 1-800-FDA-1088.



AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.