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Announcer:

A guide to receiving AMVUTTRA

Please view the entire video for Important Safety Information and visit amvuttra.com for the full Prescribing Information, or scan the QR code at the end of the video.

Patient 1:

If you’re getting ready to receive AMVUTTRA, you want to feel prepared. I’m here to walk you through some basic information.

AMVUTTRA is a prescription medicine that is given as an injection once every 3 months by a healthcare provider.

That’s only 4 times a year. You and your doctor will decide where is most convenient to receive your treatment.

I visit my doctor’s office, but some people go to a nearby clinic. It can vary based on your doctor or insurance. If your insurance covers it, you may even be able to receive AMVUTTRA at home from a mobile healthcare provider.

If you’re like me, you may worry about getting an injection. Here’s what to expect.

AMVUTTRA comes as a prefilled syringe. It’s given by a healthcare provider so you can feel confident you’re getting the full dose.

AMVUTTRA is given as an injection with a short needle, in the upper arm, thigh, or abdomen. I usually get mine in my arm.

After cleaning the area, the healthcare provider will pinch your skin. Next, they’ll give you AMVUTTRA subcutaneously, which means just under the skin.

The administration process will only take a few minutes. It’s a good idea to set up your next appointment before you leave.

If you’re receiving AMVUTTRA at home, there are a few more things you need to know.

Patient 2:

Let’s talk about at-home administration by a healthcare provider. My insurance covers it, but it’s not an option for everyone.

If you’re eligible to receive AMVUTTRA at home, the specialty pharmacy will call to set up your appointment. Now, before your appointment, the specialty pharmacy will deliver AMVUTTRA. You may need to sign for the package, so make sure someone is home.

Your first shipment of AMVUTTRA will include a welcome packet and supplies for your appointment. Don’t open the medicine carton or syringe.

AMVUTTRA can be stored in the fridge or at room temperature. If you keep yours in the fridge like me, make sure you have a dedicated space for it. And don’t freeze it.

On the day of your appointment, take AMVUTTRA out of the fridge 30 minutes before the nurse arrives. That way it can reach room temperature. Then prepare a space to receive your injection.

You’ll need a clean surface and a comfortable seat. Now, once the nurse shows up, they’ll clean the injection site, pinch your skin, and use the short needle to give you AMVUTTRA subcutaneously. That means just under the skin.

The administration process will only take a few minutes. And before the nurse leaves, it’s a good idea to confirm your next appointment.

Announcer:

AMVUTTRA may cause reactions at the injection site such as bruising, redness, pain, itching, and warmth.

Questions about accessing treatment? Contact Alnylam Assist. In case of an emergency, call 9-1-1.

Important Safety Information and Indications.

Important Safety Information.

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause low vitamin A levels.

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision, for example, night blindness while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA were pain in the arms or legs, pain in the joints, shortness of breath, and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the US Food and Drug Administration (FDA). Visit www.fda.gov/medwatch or call 1-800-FDA-1088.

Indications.

What is AMVUTTRA?
AMVUTTRA is a prescription medicine that treats the cardiomyopathy of wild type or hereditary, transthyretin-mediated amyloidosis (ATTR-CM) in adults to reduce heart related death, hospital stays and urgent visits.
Polyneuropathy caused by hereditary transthyretin-mediated amyloidosis (hATTR-PN) in adults.

For additional information about AMVUTTRA, please see the full Prescribing Information or scan the QR code.

Learn more about treatment with AMVUTTRA at amvuttra.com.