Educational resources for you and your family

Treatment Brochure

Learn more about treatment with AMVUTTRA®

Caregiver Brochure

Discover tips on supporting a loved one receiving treatment with AMVUTTRA

Treatment Journal & Planner

Keep track of your treatment

Alnylam Assist® Brochure

Learn more about available patient support

Doctor Discussion Guide

Fill out this guide and use it to facilitate conversations with your doctor. Try our interactive guide.


Hear from those who have experience with AMVUTTRA

Watch the video to learn more about the treatment process with AMVUTTRA
Treatment Process With AMVUTTRA video thumbnail

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Alnylam Patient Education Liaison (PEL)

Education is available for you and your family

An Alnylam PEL can provide education to help you and your family better understand hATTR amyloidosis and answer your questions about AMVUTTRA.

PELs are employees of Alnylam Pharmaceuticals. They are not acting as healthcare providers and are not part of your healthcare team.

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.


What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit, or call 1-800-FDA-1088.



AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.