Disease Overview

What is hereditary ATTR (hATTR) amyloidosis?

hATTR amyloidosis is a rare and rapidly progressive condition caused by a variant, or change, in the transthyretin (TTR) gene. This change in the TTR gene may also be referred to as a mutation.

It runs in the family
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It runs in the family
  • If one parent has hATTR amyloidosis, each child will have a 50% chance of inheriting the genetic variant that causes the condition
  • A family member may inherit the TTR gene variant, but having the variant does not necessarily mean they will develop hATTR amyloidosis
  • The age range that symptoms appear typically ranges from the mid-20s to the mid-60s
It can be difficult to recognize
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It can be difficult to recognize
  • hATTR amyloidosis is often misdiagnosed because its symptoms resemble those of other conditions
  • If your doctor suspects that you have hATTR amyloidosis, they may order further tests to make a diagnosis. Some common tests include:
    • Genetic testing
    • Tissue biopsy
  • This is not a complete list of tests that can help diagnose hATTR amyloidosis
Being diagnosed with hATTR amyloidosis
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Being diagnosed with hATTR amyloidosis
  • It can be difficult to come to terms with a diagnosis of hATTR amyloidosis, and you may have questions about the disease
  • It’s important to know that you’re not alone. There are resources available to help you understand your diagnosis

What are the symptoms of hATTR amyloidosis?

There are many different symptoms of hATTR amyloidosis, and they can affect several parts of the body, including the nerves, heart, and digestive system.

Nerve damage that affects sensation, movement, strength, the digestive system, and other bodily functions may be referred to as polyneuropathy.

Choose below to see:

Nerve pain

Symptoms related to nerves in hands, feet, arms, and legs

  • Burning pain
  • Carpal tunnel syndrome
  • Decreased reflexes
  • Difficulty walking
  • Temperature sensitivity loss
  • Tingling and/or numbness
  • Weakness
Icon Stomach

Symptoms related to the digestive system

  • Diarrhea
  • Feeling full quickly
  • Nausea
  • Severe constipation
  • Unintentional weight loss
  • Vomiting 
Heart icon

Symptoms related to the heart

  • Abnormal heart rhythms and palpitations (atrial fibrillation)
  • Fatigue
  • Heart failure
  • Leg swelling (edema)
  • Shortness of breath
Autonomic icon

Symptoms related to other bodily functions

  • Abnormal sweating
  • Difficulty urinating
  • Dizziness upon standing
  • Recurrent urinary tract infections
  • Sexual dysfunction

Other symptoms of hATTR amyloidosis include: 

  • Blurred or spotty vision
  • Glaucoma
  • Floaters in eyes
  • Kidney dysfunction

This is not a complete list of symptoms that may be experienced with hATTR amyloidosis. 

Nerve pain

Symptoms related to nerves in hands, feet, arms, and legs

  • Burning pain
  • Carpal tunnel syndrome
  • Decreased reflexes
  • Difficulty walking
  • Temperature sensitivity loss
  • Tingling and/or numbness
  • Weakness
Icon Stomach

Symptoms related to the digestive system

  • Diarrhea
  • Feeling full quickly
  • Nausea
  • Severe constipation
  • Unintentional weight loss
  • Vomiting 
Heart icon

Symptoms related to the heart

  • Abnormal heart rhythms and palpitations (atrial fibrillation)
  • Fatigue
  • Heart failure
  • Leg swelling (edema)
  • Shortness of breath
Autonomic icon

Symptoms related to other bodily functions

  • Abnormal sweating
  • Difficulty urinating
  • Dizziness upon standing
  • Recurrent urinary tract infections
  • Sexual dysfunction

Other symptoms of hATTR amyloidosis include: 

  • Blurred or spotty vision
  • Glaucoma
  • Floaters in eyes
  • Kidney dysfunction

This is not a complete list of symptoms that may be experienced with hATTR amyloidosis. 

Choose below to see:

Nerve pain

Symptoms related to nerves in hands, feet, arms, and legs

  • Burning pain
  • Carpal tunnel syndrome
  • Decreased reflexes
  • Difficulty walking
  • Temperature sensitivity loss
  • Tingling and/or numbness
  • Weakness
Icon Stomach

Symptoms related to the digestive system

  • Diarrhea
  • Feeling full quickly
  • Nausea
  • Severe constipation
  • Unintentional weight loss
  • Vomiting 
Heart icon

Symptoms related to the heart

  • Abnormal heart rhythms and palpitations (atrial fibrillation)
  • Fatigue
  • Heart failure
  • Leg swelling (edema)
  • Shortness of breath
Autonomic icon

Symptoms related to other bodily functions

  • Abnormal sweating
  • Difficulty urinating
  • Dizziness upon standing
  • Recurrent urinary tract infections
  • Sexual dysfunction

Other symptoms of hATTR amyloidosis include: 

  • Blurred or spotty vision
  • Glaucoma
  • Floaters in eyes
  • Kidney dysfunction

This is not a complete list of symptoms that may be experienced with hATTR amyloidosis. 

Nerve pain

Symptoms related to nerves in hands, feet, arms, and legs

  • Burning pain
  • Carpal tunnel syndrome
  • Decreased reflexes
  • Difficulty walking
  • Temperature sensitivity loss
  • Tingling and/or numbness
  • Weakness
Icon Stomach

Symptoms related to the digestive system

  • Diarrhea
  • Feeling full quickly
  • Nausea
  • Severe constipation
  • Unintentional weight loss
  • Vomiting 
Heart icon

Symptoms related to the heart

  • Abnormal heart rhythms and palpitations (atrial fibrillation)
  • Fatigue
  • Heart failure
  • Leg swelling (edema)
  • Shortness of breath
Autonomic icon

Symptoms related to other bodily functions

  • Abnormal sweating
  • Difficulty urinating
  • Dizziness upon standing
  • Recurrent urinary tract infections
  • Sexual dysfunction

Other symptoms of hATTR amyloidosis include: 

  • Blurred or spotty vision
  • Glaucoma
  • Floaters in eyes
  • Kidney dysfunction

This is not a complete list of symptoms that may be experienced with hATTR amyloidosis. 

AMVUTTRA™ does not treat all of the symptoms of hATTR amyloidosis.

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA™ (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.

Important Safety Information and Indication

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA™ (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA™ (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.

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