How AMVUTTRA Works

Hero image of Al treated with AMVUTTRA® (vutrisiran) and his caregiver Deborah

How does AMVUTTRA® work?

AMVUTTRA works with your body’s natural system to rapidly knock down TTR. It decreases the amount of TTR protein made in the liver, which leads to fewer harmful amyloid deposits being formed.

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How hATTR amyloidosis develops

How Amvuttra works

AMVUTTRA starts decreasing TTR protein after the first dose, which lasts with continued treatment. TTR protein was reduced by an average of 88% over 18 months in a clinical study of adults treated with AMVUTTRA.

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Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA^® (vutrisiran)?

AMVUTTRA can cause:

Low Vitamin A Levels

Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.

For healthcare providers