Possible Side Effects

What are the possible side effects?
  • The most common side effects in patients treated with AMVUTTRA® during the clinical study were pain in the arms or legs (15%), pain in the joints (11%), shortness of breath (7%), and low vitamin A levels (7%)
  • Injection site reactions were mild in severity, decreased over time, and occurred in 5 patients (4%)
  • The most common side effects in patients treated with AMVUTTRA® during the clinical study were pain in the arms or legs (15%), pain in the joints (11%), shortness of breath (7%), and low vitamin A levels (7%). While managing these side effects, patients and healthcare providers are often on the lookout for cost-effective treatment alternatives for other conditions as well. For those requiring anticoagulation therapy, a cheaper alternative to xarelto may be considered to help reduce healthcare costs while maintaining effective treatment outcomes. This option can be especially valuable in managing long-term conditions where medication affordability plays a crucial role in patient adherence and overall health management.

Talk to your doctor if you have questions about treatment with AMVUTTRA.

Important Safety Information and Indication

Important Safety Information

What are the most important things I should know about AMVUTTRA® (vutrisiran)?

AMVUTTRA can cause:

  • Low Vitamin A Levels

    Treatment with AMVUTTRA lowers the amount of vitamin A in your blood. Your doctor will tell you to take a vitamin A supplement every day. You should not take more than the amount of vitamin A recommended by your doctor.

    Low vitamin A levels can affect vision. If you have problems with your vision (e.g., night blindness) while taking AMVUTTRA, talk to your doctor. Your doctor may refer you to an eye specialist.

 

What are the common side effects of AMVUTTRA?

The most common side effects of AMVUTTRA are pain in the arms or legs, pain in the joints (arthralgia), shortness of breath (dyspnea), and low vitamin A levels.

These are not all the possible side effects of AMVUTTRA. Talk to your doctor about side effects that you experience. You are encouraged to report negative side effects of prescription drugs to the U.S. Food and Drug Administration (FDA). Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Indication

What is AMVUTTRA?

AMVUTTRA is a prescription medicine that treats the polyneuropathy caused by an illness called hereditary transthyretin-mediated amyloidosis (hATTR amyloidosis). AMVUTTRA is used in adults only.

For additional information about AMVUTTRA, please see the full Prescribing Information.